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This depends on several factors, but in general chiltran>ditran>hemotoxin>xeroderma will do all you ever need. Your defensive toxin is avidya: intelligence-based damage professions are probably the ones giving you the kind of trouble where taking less damage is your best recourse. It's a non-focusable orphine cure and pairs very well with the passive afflictions from the transfix pet.2) Toxins
As mentioned, trans frost gives 25% cold mitigation. A lot of people are going to be carrying something closer to 40% due to other defences. Don't be discouraged by that seeming like a large chunk of your damage being resisted - it is, but keep in mind that with nausea, dryblood, chiltran, and the general damage of your various attacks you whittle people down FAST. It doesn't need to do the full amount of their max health in damage (though this can be achieved if you're a jerk).3) Bloodfreeze
Both of these ignore the aura of rebounding, and that is where they really shine. Smash is okay against physical profs. Batter is great all day every day. As with a large part of Outrider offense, however, using batter is certainly a situational choice. Usually you'll use it if the target has rebounding and neither of the afflictions (okay) or one of the afflictions (best) to continue your offense without needing to pierce. If they have both afflictions, and not all three from blacken, a blackened pierce might serve better.4) Batter/Smash